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Julia Oxford, Ph.D.

Julia Oxford, Research Ad, jkProfessor, Department of Biological Sciences
Year arrived at BSU: 2000
Mailing Address:
Department of Biological Sciences
Boise State University
1910 University Dr.
Boise, ID 83725-1515
Office Location: Science Building, Room 211
Office Number: 208-426-2395
Office Fax: 208-426-1040
E-Mail Address: joxford@boisestate.edu

Current research projects

  • Molecular Mechanisms of Cellular Mechanoreception in Bone
  • Regulation of cell signaling by Col11a1 during craniofacial development in the zebrafish
  • Extracellular Matrix is a Key Factor in Cancer Progression
  • The Effects of Simulated Microgravity on Articular Cartilage
  • Induction of Early Stages of Osteoarthritis

Map-making for matrix molecules

Cartilage is central to the proper growth within the growth plate and in articulation of the joint. The cartilage tissue is composed of chondrocytes and a dense extracellular matrix, which is in turn, composed of water, proteoglycans and collagens. Over 200 of 2400 chondrocyte gene products are extracellular. Understanding these complex gene families will make major improvements in the quality of life for those dealing with a broad spectrum of arthritic syndromes. Brown et al. have begun exploring this territory with tools including LC/MS-MS/1-D electrophoresis and affinity chromatography. False discovery rates were determined using decoy searches. Interactions were identified using STRING, which integrates protein–protein data from gene fusion, co-occurrence, experimental, …surface plasmon resonance and solution equilibrium.

Brown, R. J. et al., Proteomics 2011, 11, 4660–4676.
PROTEOMICS–Collagen Network Interactions

ACADEMIC DEGREES

Doctor of Philosophy, Biochemistry and Biophysics, 1986
Washington State University, Pullman, WA
Dissertation: “Export of Protein in Escherichia coli”
Advisor:  Prof. Linda L. Randall
Department of Biochemistry and Biophysics
Washington State University

Master of Sciences, Biochemistry and Biophysics, 1985
Washington State University, Pullman, WA

Bachelor of Arts, Chemistry and Biology (cum Laude), 1981
Linfield College, McMinnville, OR

Positions Held

  • Professor, Department of Biological Sciences, Boise State University, 2008-present
  • Affiliate Faculty, University of Washington, School of Medicine, Department of Biochemistry, 2003-2010
  • Affiliate Faculty, University of Idaho, Dept of Microbiology, Molecular Biology and Biochemistry, 2002-present
  • Associate Professor, Department of Biology, Boise State University, 2003-2008
  • Assistant Professor of Biology, Boise State University, 2000-2003.
  • Affiliate Faculty, Oregon Health Sciences University, School of Dentistry, 2000-2002.
  • Research Assistant Professor, Integrative Biosciences Department (formerly Oral Molecular Biology), School of Dentistry, Biochemistry and Molecular Biology, School of Medicine, Oregon Health Sciences University, 1995-2000.
  • Visiting Assistant Professor of Clinical Sciences, Equine Orthopaedics, Colorado State University, 1996-1998.

Honors and Awards

  • Arthritis Investigator Award, Arthritis Foundation, 1996.Gerlinger Research Foundation Award, 1999.
  • Oregon Medical Research Foundation Award, 2000.
  • Boise State University Foundation Scholar Award, Research and Creative Activity, 2006.
  • Lori and Duane Stueckle Dean’s Distinguished Faculty Award, 2005-2009
  • MMACHS Distinguished Lecture Series February 10, 2011
  • Boise State University Distinguished Professor 2011

TEACHING

Graduate courses at Boise State University:

Biology/Materials Science/Mechanical&Biomedical Engineering 577 Biomaterials Science
Biology 598 Biomaterials Graduate Seminar
Biology 597 Biochemistry of Cell Signaling
Biology 597 Introduction to Bioinformatics
Biology 465/565 Advanced Topics in Molecular Biology Techniques
Biology 466/566 Advanced Topics in Cancer and Developmental Biology
Biology 567 Extracellular Matrix in Development and Disease
Biology 596 Directed Research, Boise State University
Biology 551 Developmental Biology, lecture and laboratory
Biology 543 Advanced Developmental Biology
Biology 650 Scientific Writing in the Biomedical Sciences
BMOL 605 Scientific Proposal Writing

Undergraduate Courses at Boise State:

Biology/Materials Science/ Mechanical&Biomedical Engineering 477 Biomaterials Science
Biology 497 Biochemistry of Cell Signaling
Biology 497 Introduction to Bioinformatics
Biology 191 General Biology
Biology 493 Internship in Laboratory Research
Biology 451 Developmental Biology, lecture and laboratory
Biology 443 Advances in Developmental Biology
Biology 320 Cell Biology
Biology 202 General Zoology lecture and laboratory
Chem 405 Research in Chemistry

Undergraduate Student Research Projects

-Vertically Integrated Projects

Alexandria Hughes, 2014 – 2016

–Hughes A, Oxford AE, Tawara K, Jorcyk CL, Oxford JT. Endoplasmic Reticulum Stress and Unfolded Protein Response in Cartilage Pathophysiology; Contributing Factors to Apoptosis and Osteoarthritis. Int J Mol Sci. 2017 Mar 20;18(3). pii:E665. doi: 10.3390/ijms18030665.

–Hughes AN, Oxford JT. A lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events. Hepat Med. 2014 Mar 6;6:15-23. doi: 10.2147/HMER.S57500. eCollection 2014.  PMCID: PMC3953741

Alexandra Oxford, 2016,

–Oxford, AE, Jorcyk CL, Oxford JT. Neuropathies of Stüve-Wiedemann Syndrome due to mutations in leukemia inhibitory factor receptor (LIFR) gene. J Neurol Neuromedicine. 2016;1(7):37-44.

Tyler Bates, 2012, Osteochondritis dissecans
– Recipient of the Idaho INBRE Summer Undergraduate Research Fellowship, 2012
– Recipient of Boise State University Student Research Initiative Program, 2013

Kenneth Weekes, 2011 – 2013, The role of Hedgehog signaling in Tooth regeneration, Scale regeneration as a model for tooth regeneration in the zebrafish
– Recipient of the Sigma Xi Grant-In-aid-of-Research, 2012
– Recipient of Boise State University Student Research Initiative Program, 2013

Saige Harrington, 2012, Diabetes and Osteoarthritis

Travis Baker, 2012, Cartilage regeneration, Microgravity and mechanotransduction

Kelci Burgess, 2010, Oncostatin M in Osteoarthritis

Neda Shefa, 2009 –2012, Chondrocyte model systems for regenerative medicine, Abdominal aortic aneurysms
– Posters on the Hill Presentation, 2011
– Master of Science in Biology program, 2012-present

Stephanie Frahs, 2009-2012, Mechanotransduction in bone cells; biomaterials; PTHrP signaling
– Recipient of the NASA Microgravity University Award, 2011
– Sigma Xi Grant in Aid of Research Award, 2011

Dawn Mikelonis, 2009-2010, Zebrafish as model system for eye development
– Recipient of the NASA Microgravity University Award
– Recipient of the Idaho INBRE Summer Undergraduate Research Fellowship

Jonathan Reeck, 2009-1010, Molecular biology analysis of Col11a1DVR transgenic mouse
– Recipient of Sigma Xi Grant in Aid of Research, 2011

Benjamin Davis, 2006-2011, LC-Mass spectrometry, Proteomics
– Recipient of INBRE Summer Undergraduate Research Fellowship, 2009
– Recipient of the NASA Microgravity University Award, 2011

Luke Woodbury, 2006-2011, Histological characterization of the Col11a1deltaVR mouse model for osteoarthritis; Protein: carbohydrate interactions, protein purification, monomer-dimer equilibrium analysis by AUC, SEC-MALS
– Undergraduate Research Symposium Presentation, 2006, 2007, 2008, 2009
– AAAS Pacific Division poster presentation, 2007
– INBRE Biomedical Research Fellow, 2009

Jonathan Hendersen, 2006-2009, Atomic Force Microscopy
– Undergraduate Research Symposium Presentation  2007,2008, 2009
– INBRE Summer Undergraduate Research Fellowship 2008, 2009

More Undergraduate Research Projects

Graduate Student Research Projects

Brad Grimm, 2016 – present, Collagen fibrillogenesis

Aaron Sheetz, 2016 – present, Ciprofloxacin effect on tendon health

Kenneth Weekes, 2013- present, The role of Hedgehog signaling in Tooth regeneration, Scale regeneration as a model for tooth regeneration in the zebrafish
– Recipient of the Sigma Xi Grant-In-aid-of-Research, 2012
– Recipient of Boise State University Student Research Initiative Program, 2013

Anthony Hafez, 2012-present, Mineralization of the developing skeleton

Neda Shefa, 2012-present, PTHrP and alternative splicing in skeletal development

Jonathon Reeck, 2010-present, Zebrafish model system for osteogenesis
– Recipient of Sigma Xi Grant-in-aid of research, 2011

Ming Fang, 2007-2010,  Zebrafish Craniofacial Development
– Recipient of ISU Molecular Core Facility Grant for DNA Sequencing
– First author on two papers

Kendra Coonse, 2006-2010, Master of Science, Collagen-Biglycan interactions

Katey Anderson, 2005-2011, Proteomic analysis of cartilage extracellular matrix

Kelly Willius, 2005-2006, Bone regeneration in the zebrafish
– Recipient of NASA-ISGC Graduate Student Fellowship, 2006-2007

Nathan Hoskins 2007-2009, Master of Science, Col11a1 regulates bone microarchitecture

More Graduate Research Projects

PH.D. Student Research Projects

Jonathon Reeck, 2010-present, Zebrafish model system for osteogenesis
– Recipient of Sigma Xi Grant-in-aid of research, 2011

Publications

68.   Hughes A, Oxford AE, Tawara K, Jorcyk CL, Oxford JT. Endoplasmic Reticulum Stress and Unfolded Protein Response in Cartilage Pathophysiology; Contributing Factors to Apoptosis and Osteoarthritis. Int J Mol Sci. 2017 Mar 20;18(3). pii: E665. doi: 10.3390/ijms18030665.

67.   Oxford AE, Jorcyk CL, Oxford JT. Neuropathies of Stüve-Wiedemann Syndrome due to mutations in leukemia inhibitory factor receptor (LIFR) gene. J Neurol Neuromed. 2016, 1(7): 37-44.

66.   Lamb CL, Cholico GN, Perkins DE, Fewkes MT, Oxford JT, Lujan TJ, Morrill EE, Mitchell KA. Aryl Hydrocarbon Receptor Activation by TCDD Modulates Expression of Extracellular Matrix Remodeling Genes during Experimental Liver Fibrosis. Biomed Res Int. 2016;2016:5309328. PMCID: PMC5031815. 

65.   Oxford, Julia T(Feb 2016) Molecular Genetics of Stüve–Wiedemann Syndrome. In: Encyclopedia of Life Science (eLS). John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0026480]

64.   Jorcyk, C, Mikelonis, D, Tawara, K, Oxford, JT.. Stuve-Wiedemann syndrome. Orphanet. March, 2016;http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=3206.

63.   Hafez A, Squires R, Pedracini A, Joshi A, Seegmiller RE, Oxford JT. Col11a1 Regulates Bone Microarchitecture during Embryonic Development. J Dev Biol. 2015;3(4):158-176. PMCID: PMC4711924.

62.   Parker H, Conway E, Goldsberry J, Jeffries S, Price E, Oxford JT.  Genetic and Molecular Aspects of DiGeorge Syndrome. (2015) BIOS. Vol. 86(2): 109-117. doi: 10.1893/0005-3155-86.2.109.

61.   Pu X, Oxford JT. Proteomic analysis of tissue engineered cartilage. (2015) Cartilage Tissue Engineering; Methods in Molecular Biology. 1340:263-78. doi: 10.1007/978-1-4939-2938-2_19.

60.   Goyden J, Tawara K, Hedeen D, Willey JS, Oxford JT, Jorcyk CL. The Effect of OSM on MC3T3-E1 Osteoblastic Cells in Simulated Microgravity with Radiation. PLoS One. 2015 Jun 1;10(6):e0127230. doi: 10.1371/journal.pone.0127230. eCollection 2015. PMCID: PMC4452373.

59.   Ryan RE, Martin B, Mellor L, Jacob RB, Tawara K, McDougal OM, Oxford JT, Jorcyk CL. Oncostatin M binds to extracellular matrix in a bioactive conformation: implications for inflammation and metastasis. Cytokine. 2015 Mar;72(1):71-85. PMCID: PMC4328881.

58.   Mellor LF, Baker TL, Brown RJ, Catlin LW, Oxford JT. Optimal 3D culture of primary articular chondrocytes for use in the rotating wall vessel bioreactor. (2014) Aviat Space Environ Med. Aug;85(8):798-804. doi: 10.3357/ASEM.3905.2014. PMCID: PMC4207436.

57.   Jacobs JC Jr, Shea KG, Oxford JT, Carey JL. Fluoroquinolone use in a child associated with development of osteochondritis dissecans. (2014) BMJ Case Rep.  Sep 16. pii: bcr2014204544. doi: 10.1136/bcr-2014-204544. PMC4166236.

56.   Bates JT, Jacobs JC, Jr, Shea KG, Oxford JT. Emerging genetic basis of osteochondritis dissecans. (2014) Clin. Sports Med.  33(2):199-220. PMC3976886.

55.   Hughes AN, Oxford JT. A lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events. (2014) Hepatic Medicine: Evidence and Research. Mar 6 6:15-23. PMC3953741.

54.   Mikelonis D, Jorcyk CL, Tawara K, Oxford JT. Stüve-Wiedemann syndrome: LIFR and associated cytokines in clinical course and etiology. (2014) Orphanet J Rare Dis. Mar 12;9(1):34. doi: 10.1186/1750-1172-9-34. PMC3995696.

53.   McDougal OM, Cornia N, Sambasivarao SV, Remm A, Mallory C, Oxford JT, Maupin CM, Andersen T. Homology modeling and molecular docking for the science curriculum. (2014) Biochem Mol Biol Educ. Mar;42(2):179-82. doi: 10.1002/bmb.20767. Epub 2013 Dec 20. PubMed PMID: 24376157.

52.   Bullock C, Cornia N, Jacob R, Remm A, Peavey T, Weekes K, Mallory C, Oxford JT, McDougal OM, Andersen TL. DockoMatic 2.0: high throughput inverse virtual screening and homology modeling. (2013) J Chem Inf Model. Aug 26;53(8):2161-70. doi: 10.1021/ci400047w. Epub 2013 Aug 8.  PMC3916141.

51.   Berger JM, Rohn TT, Oxford JT. Autism as the Early Closure of a Neuroplastic Critical Period Normally Seen in Adolescence. (2013) Biol Syst Open Access. Aug 20;1. doi: 10.4172/2329-6577.1000118.  PMC3864123.

50.   Shea KG, Jacobs JC, Carey JL, Anderson AF. Oxford JT. Osteochondritis Dissecans Knee Histology Studies Have Variable Findings and Theories of Etiology, Clinical Orthopaedics and Related Research 2012 in press.

49.  Fang M, Jacob R, McDougal O, Oxford JT., Minor fibrillar collagens, variable regions alternative splicing, intrinsic disorder, and tyrosine sulfation. Protein Cell. 2012 Jun;3(6):419-33.

48.  McDougal,O.M., Mallory, C., Warner, L.R., Oxford, J.T. “Predicted structure and binding motifs of alpha 1 (XI) collagen” 2011, JBio (GSTF International Journal on Bioinformatics and Biotechnology), vol. 1:43-48.

47. Mallory C , McDougal OM , Oxford JT. Collagen Type XI alpha-1 Chain Amino Propeptide Structural Model and Glycosaminoglycan Interactions in Silico, in Proceedings of 2011 International Conference on Bioinformatics & Computational Biology (ISBN #: 1-60132-172-4/CSREA), Editors: Hamid R. Arabnia and Quoc-Nam Tran, pp.: 632-635, Las Vegas, USA, 2011

46.  Brown, R., Mallory, C., McDougal, O.M., Oxford, J.T. “Proteomic analysis of Col11a1-associated protein complexes”. (2011) PROTEOMICS, 11(24):4660-76.

45.  Tawara, Kenneth, Oxford, Julia Thom, Jorcyk, CL. “Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies.” (2011)  Cancer Management Research, 2011;3:177-89. Epub 2011 May 18

44.  Jeff P. Gorski, Nichole T. Huffman, Sridar Chittur, Ronald J. Midura, Claudine Black, Julie Oxford, and Nabil G. Seidah  Inhibition of SKI-1 proprotein convertase and caspase-3 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization, J Biol Chem. 2010 Nov 13. [Epub ahead of print]

43.  Fang M, Adams JS, McMahan BL, Brown RJ, Oxford JT. The expression patterns of minor fibrillar collagens during development in zebrafish Gene Expr Patterns 2010 Oct-Dec;10(7-8):315-22. Epub 2010 Jul 18, PMC2956583 [Available on 2011/10/1]

42.  Toumpoulis IK, Oxford JT, Cowan DB, Anagnostopoulos CE, Rokkas CK, Chamogeorgakis TP, Angouras DC, Shemin RJ, Navab M, Ericsson M, Federman M, Levitsky S, McCully JD. “Differential expression of collagen type V and XI alpha-1 in human ascending thoracic aortic aneurysms”, (2009), Ann Thorac Surg.  88:506-13.

41.  Yingst, S, Cole, J., Warner, L., Bloxham, K., Brown, R., Kenoyer, L., Knowlton, B., Oxford, JRT., “Characterization of Collagenous Matrix Assembly in a Chondrocyte Model System” (2009) Journal of Biomedical Materials Science, 90:247-55.

40. Takumi Takata, Julie T Oxford, Borries Demeler, and Kirsten J Lampi, “Deamidation destabilizes and triggers aggregation of a lens protein, A3-crystallin”, (2008) Protein Science. 17:1565-75. PMCID: PMC2525517 [Available on 09/01/09]

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